247719/readme.html at main · ModelDBRepository/247719 · GitHub

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  The models for the paper:<p>

    Vasalou C, Henson MA (2010) A multiscale model to investigate
    circadian rhythmicity of pacemaker neurons in the suprachiasmatic
    nucleus.
    <a href="http://dx.doi.org/10.1371/journal.pcbi.1000706">PLoS Comput Biol</a> 6:e1000706
    [<a href="https://www.ncbi.nlm.nih.gov/pubmed?holding=modeldb&term=20300645">PubMed</a>]
  <p/>
  are available at the biomodels website:<p/>
  <a href="https://www.ebi.ac.uk/biomodels/BIOMD0000000246#Files">https://www.ebi.ac.uk/biomodels/BIOMD0000000246#Files</a>
  <p/>

  <p/> Example: To recreate a few traces in COPASI from figure 2 in
  the paper: import the downloaded xml (SBML) file into COPASI, change
  the Duration to more than 100 hours (172 here) and the interval
  point to 0.1 hours. The more than 100 hours lets the model
  stabilize. Create a few graphs (use Plots under Output
  specifications). Running (click Run under Time Course window - see
  below image)) creates the graphs.<p/>

  <img src="./screenshot1.png" alt="screenshot 1" width="550"><p/>
  (Above image of COPASI simulator ready to run.)
  <img src="./screenshot2.png" alt="screenshot 2" width="550"><p/>
  (Above traces are I Na, g K, Ca, and firing rate plotted vs hours. Each cycle is 24 hours.)
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