diff --git a/Papers/NAR_Update_2026/latex/sections/methods_council_direction.tex b/Papers/NAR_Update_2026/latex/sections/methods_council_direction.tex index 38592599..698a602f 100644 --- a/Papers/NAR_Update_2026/latex/sections/methods_council_direction.tex +++ b/Papers/NAR_Update_2026/latex/sections/methods_council_direction.tex @@ -1,5 +1,6 @@ %% Direction assignment from reaction chemistry (LLM ensemble). -%% \TBD values pending the full-database run, in progress. +%% Run complete over all 45,644 reactions. The one remaining \TBD is the +%% supplementary reference, pending final numbering. \subsection{Direction assignment from reaction chemistry}\label{sec:methods-council} Thermodynamic direction assignment is bounded by estimate coverage: a reaction @@ -53,11 +54,11 @@ \subsection{Direction assignment from reaction chemistry}\label{sec:methods-coun so individual assignments can be reviewed rather than accepted in aggregate. Two properties of the method bear on how the calls should be used. The ensemble commits to a direction far more readily than the thermodynamic rules -do, abstaining on \TBD[pct]\% of reactions where the rules decline on a -substantial fraction of the database, so it supplies calls where none -currently exist rather than reproducing the ones that do. And its stated -confidence does not distinguish its correct calls from its incorrect ones, so -confidence is not a usable filter for downstream integration. A systematic +do, abstaining on 1.7\% of the reaction set where the existing rules decline +on 48.7\% of it, so it supplies calls where none currently exist rather than +reproducing the ones that do. And its stated confidence does not distinguish +its correct calls from its incorrect ones, so confidence is not a usable +filter for downstream integration. A systematic evaluation against measured equilibrium constants, and against the model-level consequences of adopting these calls, is deferred to follow-up work.