diff --git a/Include/pyport.h b/Include/pyport.h
index c6cc47f7a14103d..abdaeb822729399 100644
--- a/Include/pyport.h
+++ b/Include/pyport.h
@@ -311,7 +311,7 @@ extern "C" {
  * its time must use it. Use a profiler when running performance benchmark
  * suite to find these functions.
  */
-#if defined(__GNUC__) \
+#if _Py__has_attribute(hot) || defined(__GNUC__) \
     && ((__GNUC__ >= 5) || (__GNUC__ == 4) && (__GNUC_MINOR__ >= 3))
 #define _Py_HOT_FUNCTION __attribute__((hot))
 #else
diff --git a/Misc/NEWS.d/next/Build/2026-11-06-09-16-30.gh-issue-161467.oSuzx_.rst b/Misc/NEWS.d/next/Build/2026-11-06-09-16-30.gh-issue-161467.oSuzx_.rst
new file mode 100644
index 000000000000000..ae34c60e989ead1
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2026-11-06-09-16-30.gh-issue-161467.oSuzx_.rst
@@ -0,0 +1 @@
+Enable the use of ``__attribute__((hot))`` when building CPython with Clang and other compilers that support it.