diff --git a/alembic/autogenerate/compare/comments.py b/alembic/autogenerate/compare/comments.py
index 8db56606..8fb2e80b 100644
--- a/alembic/autogenerate/compare/comments.py
+++ b/alembic/autogenerate/compare/comments.py
@@ -34,8 +34,9 @@ def _compare_column_comment(
     if not autogen_context.dialect.supports_comments:
         return PriorityDispatchResult.CONTINUE
 
-    metadata_comment = metadata_col.comment
-    conn_col_comment = conn_col.comment
+    impl = autogen_context.migration_context.impl
+    metadata_comment = impl.normalize_comment(metadata_col.comment)
+    conn_col_comment = impl.normalize_comment(conn_col.comment)
     if conn_col_comment is None and metadata_comment is None:
         return PriorityDispatchResult.CONTINUE
 
@@ -70,19 +71,23 @@ def _compare_table_comment(
     if conn_table.comment is None and metadata_table.comment is None:
         return PriorityDispatchResult.CONTINUE
 
-    if metadata_table.comment is None and conn_table.comment is not None:
+    impl = autogen_context.migration_context.impl
+    conn_comment = impl.normalize_comment(conn_table.comment)
+    metadata_comment = impl.normalize_comment(metadata_table.comment)
+
+    if metadata_comment is None and conn_comment is not None:
         modify_table_ops.ops.append(
             ops.DropTableCommentOp(
-                tname, existing_comment=conn_table.comment, schema=schema
+                tname, existing_comment=conn_comment, schema=schema
             )
         )
         return PriorityDispatchResult.STOP
-    elif metadata_table.comment != conn_table.comment:
+    elif metadata_comment != conn_comment:
         modify_table_ops.ops.append(
             ops.CreateTableCommentOp(
                 tname,
-                metadata_table.comment,
-                existing_comment=conn_table.comment,
+                metadata_comment,
+                existing_comment=conn_comment,
                 schema=schema,
             )
         )
diff --git a/alembic/autogenerate/render.py b/alembic/autogenerate/render.py
index 84e21bfa..06453838 100644
--- a/alembic/autogenerate/render.py
+++ b/alembic/autogenerate/render.py
@@ -267,7 +267,7 @@ def _add_table(autogen_context: AutogenContext, op: ops.CreateTableOp) -> str:
         text += ",\nschema=%r" % _ident(op.schema)
 
     comment = table.comment
-    if comment:
+    if comment is not None:
         text += ",\ncomment=%r" % _ident(comment)
 
     info = table.info
@@ -808,7 +808,7 @@ def _render_column(
         opts.append(("system", column.system))
 
     comment = column.comment
-    if comment:
+    if comment is not None:
         opts.append(("comment", "%r" % comment))
 
     # TODO: for non-ascii colname, assign a "key"
diff --git a/alembic/ddl/impl.py b/alembic/ddl/impl.py
index be5dbb5a..e7e09f97 100644
--- a/alembic/ddl/impl.py
+++ b/alembic/ddl/impl.py
@@ -442,12 +442,12 @@ def create_table(self, table: Table, **kw: Any) -> None:
             self.dialect.supports_comments and not self.dialect.inline_comments
         )
         comment = table.comment
-        if comment and with_comment:
+        if comment is not None and with_comment:
             self.create_table_comment(table)
 
         for column in table.columns:
             comment = column.comment
-            if comment and with_comment:
+            if comment is not None and with_comment:
                 self.create_column_comment(column)
 
     def drop_table(self, table: Table, **kw: Any) -> None:
@@ -632,6 +632,9 @@ def compare_server_default(
     ):
         return rendered_inspector_default != rendered_metadata_default
 
+    def normalize_comment(self, comment: str | None) -> str | None:
+        return comment
+
     def correct_for_autogen_constraints(
         self,
         conn_uniques: set[UniqueConstraint],
diff --git a/alembic/ddl/mysql.py b/alembic/ddl/mysql.py
index 19ef3e82..a2b12716 100644
--- a/alembic/ddl/mysql.py
+++ b/alembic/ddl/mysql.py
@@ -552,7 +552,7 @@ def _mysql_colspec(
         spec += " AUTO_INCREMENT"
     if server_default is not False and server_default is not None:
         spec += " DEFAULT %s" % format_server_default(compiler, server_default)
-    if comment:
+    if comment is not None:
         spec += " COMMENT %s" % compiler.sql_compiler.render_literal_value(
             comment, sqltypes.String()
         )
diff --git a/alembic/ddl/oracle.py b/alembic/ddl/oracle.py
index c93fa4b5..72df61c8 100644
--- a/alembic/ddl/oracle.py
+++ b/alembic/ddl/oracle.py
@@ -55,6 +55,11 @@ def _exec(self, construct: Any, *args, **kw) -> CursorResult | None:
             self.static_output(self.batch_separator)
         return result
 
+    def normalize_comment(self, comment: str | None) -> str | None:
+        if comment == "":
+            return None
+        return comment
+
     def compare_server_default(
         self,
         inspector_column,
diff --git a/alembic/operations/toimpl.py b/alembic/operations/toimpl.py
index c4eef3d7..7dddbe0a 100644
--- a/alembic/operations/toimpl.py
+++ b/alembic/operations/toimpl.py
@@ -209,7 +209,7 @@ def add_column(operations: "Operations", operation: "ops.AddColumnOp") -> None:
         and not operations.impl.dialect.inline_comments
     )
     comment = column.comment
-    if comment and with_comment:
+    if comment is not None and with_comment:
         operations.impl.create_column_comment(column)
 
 
diff --git a/tests/test_autogen_diffs.py b/tests/test_autogen_diffs.py
index 2d28b02d..fe7885f6 100644
--- a/tests/test_autogen_diffs.py
+++ b/tests/test_autogen_diffs.py
@@ -2682,3 +2682,78 @@ def include_name(name, type_, parent_names):
         diffs = self._fixture(m1, m2, name_filters=include_name)
         eq_(len(diffs), 1)
         eq_(diffs[0][0], "remove_fk")
+
+
+class CompareCommentTest(AutogenFixtureTest, TestBase):
+    """Empty string comments are distinct from NULL, except on Oracle
+    where empty string equals NULL.  See #1085."""
+
+    __backend__ = True
+    __requires__ = ("comments",)
+
+    def test_column_empty_comment_no_change(self):
+        m1 = MetaData()
+        m2 = MetaData()
+
+        Table("a", m1, Column("x", Integer, comment=""))
+        Table("a", m2, Column("x", Integer, comment=""))
+
+        diffs = self._fixture(m1, m2)
+        eq_(diffs, [])
+
+    def test_column_none_to_empty_comment(self):
+        m1 = MetaData()
+        m2 = MetaData()
+
+        Table("a", m1, Column("x", Integer))
+        Table("a", m2, Column("x", Integer, comment=""))
+
+        diffs = self._fixture(m1, m2)
+        if config.db.name == "oracle":
+            eq_(diffs, [])
+        else:
+            eq_(len(diffs), 1)
+            eq_(diffs[0][0][0], "modify_comment")
+            eq_(diffs[0][0][5], None)
+            eq_(diffs[0][0][6], "")
+
+    def test_table_empty_comment_no_change(self):
+        m1 = MetaData()
+        m2 = MetaData()
+
+        Table(
+            "some_table",
+            m1,
+            Column("x", Integer, primary_key=True),
+            comment="",
+        )
+        Table(
+            "some_table",
+            m2,
+            Column("x", Integer, primary_key=True),
+            comment="",
+        )
+
+        diffs = self._fixture(m1, m2)
+        eq_(diffs, [])
+
+    def test_table_none_to_empty_comment(self):
+        m1 = MetaData()
+        m2 = MetaData()
+
+        Table("some_table", m1, Column("x", Integer, primary_key=True))
+        Table(
+            "some_table",
+            m2,
+            Column("x", Integer, primary_key=True),
+            comment="",
+        )
+
+        diffs = self._fixture(m1, m2)
+        if config.db.name == "oracle":
+            eq_(diffs, [])
+        else:
+            eq_(len(diffs), 1)
+            eq_(diffs[0][0], "add_table_comment")
+            eq_(diffs[0][1].comment, "")
+            eq_(diffs[0][2], None)
diff --git a/tests/test_autogen_render.py b/tests/test_autogen_render.py
index 7d966934..1d42e4fe 100644
--- a/tests/test_autogen_render.py
+++ b/tests/test_autogen_render.py
@@ -1400,6 +1400,17 @@ def test_render_col_with_comment(self):
             "comment='This is a comment')",
         )
 
+    def test_render_col_with_empty_comment(self):
+        c = Column("some_key", Integer, comment="")
+        Table("some_table", MetaData(), c)
+        result = autogenerate.render._render_column(c, self.autogen_context)
+        eq_ignore_whitespace(
+            result,
+            "sa.Column('some_key', sa.Integer(), "
+            "nullable=True, "
+            "comment='')",
+        )
+
     def test_render_col_comment_with_quote(self):
         c = Column("some_key", Integer, comment="This is a john's comment")
         Table("some_table", MetaData(), c)
@@ -2299,6 +2310,24 @@ def test_render_table_with_comment(self):
             ")",
         )
 
+    def test_render_table_with_empty_comment(self):
+        m = MetaData()
+        t = Table(
+            "test",
+            m,
+            Column("id", Integer, primary_key=True, comment=""),
+            comment="",
+        )
+        op_obj = ops.CreateTableOp.from_table(t)
+        eq_ignore_whitespace(
+            autogenerate.render_op_text(self.autogen_context, op_obj),
+            "op.create_table('test',"
+            "sa.Column('id', sa.Integer(), nullable=False, comment=''),"
+            "sa.PrimaryKeyConstraint('id'),"
+            "comment=''"
+            ")",
+        )
+
     def test_render_table_with_info(self):
         m = MetaData()
         t = Table(
@@ -2330,6 +2359,14 @@ def test_render_add_column_with_comment(self):
             "nullable=True, comment='This is a Column'))",
         )
 
+    def test_render_add_column_with_empty_comment(self):
+        op_obj = ops.AddColumnOp("foo", Column("x", Integer, comment=""))
+        eq_ignore_whitespace(
+            autogenerate.render_op_text(self.autogen_context, op_obj),
+            "op.add_column('foo', sa.Column('x', sa.Integer(), "
+            "nullable=True, comment=''))",
+        )
+
     def test_render_create_table_comment_op(self):
         op_obj = ops.CreateTableCommentOp("table_name", "comment")
         eq_ignore_whitespace(