🧬 epgeno

Engineering Decentralized Genomic Infrastructure, Air-Gapped Privacy & Peer-to-Peer Biological Knowledge Meshes

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epgeno is an open-source biological computing initiative dedicated to safeguarding humanity's genomic sovereignty. We engineer peer-to-peer data distribution primitives, high-throughput sequence streaming engines, and client-side privacy sandboxes that eliminate dependency on vulnerable, centralized commercial cloud silos.

┌────────────────────────────────────────────────────────────────────────┐
│                        epgeno Infrastructure Stack                     │
├──────────────────────────────────┬─────────────────────────────────────┤
│      Public P2P Swarm Layer      │     Air-Gapped Client Sandbox       │
├──────────────────────────────────┼─────────────────────────────────────┤
│ • BitTorrent v2 BEP 52 WebRTC    │ • Local-First OPFS Storage          │
│ • ClinVar/ACMG Immutable SSOT    │ • In-Browser WASM noodles Engine    │
│ • 16KB Merkle Range Slicing      │ • Zero-Egress Network Isolation     │
│ • Cloudflare R2 Viewport Seeding │ • Cryptographic Coordinate Liftover │
└──────────────────────────────────┴─────────────────────────────────────┘

Decentralized Genomic Wiki & Merkle Range Slicing Engine (plasmid.wiki)

• RFC-0001 (.plasmid): Single-container packaging combining 16KB Merkle chunks, 32-byte index directories, and interleaved reference genomes.
• RFC-0002 (plasmid-vault): Physical air-gap architecture guaranteeing private user WGS/VCF data never enters P2P swarms or cloud servers.
• WASM Range Slicing: Sub-millisecond partial genomic decoding powered by noodles in pure WebAssembly.
• WebRTC P2P Swarms: Peer-to-peer chunk exchange reducing academic lab genome hosting bandwidth costs by >90%.

• Clinical SSOT Immutability: Medical pathogenicity tiers (ClinVar/ACMG) are cryptographically immutable. All community contributions undergo peer-reviewed GitHub Pull Requests.
• Dual Licensing: Open-source crates and applications are dual-licensed under MIT OR Apache-2.0.
• Responsible Vulnerability Disclosure: Private security reporting via GitHub Security Advisories or security@epgeno.org.