sg4_DExplore is an interactive bioinformatics platform designed for the seamless exploration and functional interpretation of RNA-Seq differential expression data. Developed specifically for researchers working with DESeq2 outputs, the tool automates the tedious steps of gene ID mapping, statistical filtering, and pathway enrichment.
Principal Investigator: Dr. Saminathan Sivaprakasham Murugesan
Laboratory: Sumathi Genomics
Contact: lab@sumathigenomics.com
sg4_DExplore is an interactive bioinformatics dashboard designed for the rapid exploration, annotation, and functional interpretation of RNA-Seq differential expression data. Developed specifically for researchers working with DESeq2 outputs, the tool streamlines the transition from statistical tables to biological discovery.
- Automated Gene Annotation: Seamlessly maps Ensembl IDs to official Gene Symbols using the MyGene.info API.
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Interactive Volcano Plots: Dynamic filtering using
$|log_2 \text{Fold Change}|$ and$p_{adj}$ thresholds with real-time visualization. - Expression Heatmaps: Visualizes sample-specific variance using row-wise Z-score normalization for top differentially expressed genes.
- Functional Enrichment: Integrated pathway analysis (KEGG) through the Enrichr API.
- Publication-Ready Exports: Download annotated datasets and high-resolution interactive plots.