nonlinear-mixed-effects

Open-source nonlinear mixed-effects (NLME) modeling engine for population PK/PD and pharmacometrics, with FOCEI, SAEM, analytical PK, and ODE models.

This GitHub repository serves as documentation and reproduction source for our article: Augustin D, Lambert B, Wang K, Walz A-C, Robinson M, Gavaghan D (2023) Filter inference: A scalable nonlinear mixed effects inference approach for snapshot time series data. PLoS Comput Biol 19(5): e1011135.

Documentation for ferx, an open-source NLME platform for population PK/PD with an R package and high-performance Rust engine.