Geometric deep learning of protein–DNA binding specificity
Reproducible comparative genomics study investigating human TP53 cancer mutation hotspots across elephant TP53-related sequences, integrating sequence conservation, phylogenetic analysis, computational prioritization, and research software to explore evolutionary conservation of cancer-associated residues.
Comparative evolutionary analysis of recurrent human TP53 cancer mutation hotspots across 56 mammalian species, integrating residue-level conservation, statistical testing, phylogenetic analysis, and cancer-associated mutation data to investigate evolutionary constraints on clinically relevant TP53 residues.
DNA analyser IBP - api wrapper for bioinformatics.ibp used for creating R-loop tracker, P53predictor, G4Killer and G4Hunter analysis
Effect of point mutations on p53 tumor suppressor protein structure : RasMol visualization with RMSD, B-factor & SASA statistical analysis
AlphaFold-powered structural bioinformatics workflow for cancer-associated p53 mutations, including stability, confidence, and hotspot analysis.
P53 Atlas is an AI-powered scientific knowledge navigator focused exclusively on TP53 (p53) and its role in cancer biology. It is designed to help users explore TP53 mutations, p53 protein structures, cancer pathways, drugs, treatments, clinical trials, drug repurposing, and scientific literature in one place.
Comparative analysis of p53 protein across species
In silico p53 LNP formulation platform for predicting and ranking ionizable lipids, estimating mRNA delivery performance, and recommending cancer-specific targeting strategies from TP53 mutations.
p53/p21 dynamics encode DNA damage and shape proliferation heterogeneity (Comms Biology 2023)
PhenoRescue AI is a multi-modal artificial intelligence platform designed to accelerate phenotypic drug discovery for TP53 cancer mutations.
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